inhibition of nitric oxide production and proinflammatory cytokines by several medicinal plants

نویسندگان

zahra amirghofran

department of immunology saeed malek-hosseini

department of immunology hossein golmoghaddam

department of immunology fathollah kalantar

department of immunology mehdi shabani

چکیده

background: a number of medicinal plants have been used to treat various immunological diseases. nitric oxide (no) has an important regulatory role in the various types of inflammatory processes. objective: to investigate the no modulatory activity of the extracts of several medicinal plants native to iran including dracocephalum kotschyi, linum persicum, dionysia termeana, salvia mirzayanii, ferulago angulata and euphorbia cheiradenia. methods: the methanolic extracts of the plants were prepared and examined for their effects on the no production by lipopolysaccharide-stimulated mouse macrophages. the level of tnf-α and il-1β proinflammatory cytokines in the macrophage culture were detected using enzyme-linked immunosorbent assay. results: all the extracts at concentration of 50 μg/ml demonstrated a significant decrease in no production (p

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Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants

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Inhibition of nitric oxide production and proinflammatory cytokines by several medicinal plants.

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عنوان ژورنال:
iranian journal of immunology

جلد ۸، شماره ۳، صفحات ۱۵۹-۱۶۹

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